美高梅赌场

曹鹏秀

教授、硕士研究生导师

河北师范大学“精英计划”引进人才

河北省引进海外高层次人才，河北省特聘专家

河北省政府特殊津贴专家

联系电话：0311-80787586

电子邮件：[email protected]

所属专业、方向：生理学专业、动物细胞信号转导方向

主要学习和工作经历

1998-2002 于河北师范大学获得生物学教育专业理学学士学位  

2002-2007 于中国科美高梅赌场 遗传与发育生物学研究所获得遗传学专业理学博士学位

2008-2017 在美国Case Western Reserve University、ClevelandClinic和University of Michigan等高校或研究所进行生物医学领域的博士后研究

2018-今     为河北师范大学生理学专业动物细胞信号转导方向教师

主要教学科研工作

       2018年河北师大学任教以来，主要科研方向为(1) 肺纤维化进程分子机制研究和有效治疗策略的开发及药物筛选；(2) 雾霾引起肺部重塑的机制研究和干预策略；(3) 吸烟致肺部疾病机制研究及分子治疗策略。至今已在 Nature Medicine、Journal of Clinical Investigation 和American Journal of Respirotory Cell and Molecular Biology等期刊上发表40多篇SCI文章，获得国家发明专利2项。

       教学上，曾先后主讲《人体及动物生理学》、《人体及动物生理学实验》、《铁与人类健康》、《生物信息学》、《组织学与解剖学》和《组织学与解剖学实验》等本科生课程。主讲《动物细胞信号转导》、《生理学实验技术》、《铁代谢与人类健康》、《生物信息学》和《专业英语》等研究生课程。参与建设 3 门河北师范大学一流课程《铁与人类健康》（排名第 2）、《生物信息学》（排名第 4）和《人体及动物生理学实验》（排 名第 5）。参编高等教育教材3部，发表教学论文2篇。

主持的科研和教改项目

国家自然科学青年基金，铁通过SHH/FOXF1/ATX轴调控肺间充质细胞增殖及肺纤维化的机制研究，31900817，2020.1—2022.12。

国家自然科学面上基金，通过靶向线粒体代谢抑制肺纤维化进程及其机制研究，32071119，2021.1—2024.12。

河北省人社厅高层次人才支持项目，肺纤维化分子机制研究及治疗策略，E2018050011，2019.2—2021.12。

河北师范大学科研启动基金，异常铁代谢影响肺纤维化机制的研究，2018.1-2020.12。

河北师范大学教改项目，以科技前沿生理学综合实验为载体的本科生创新科研素质培 养，2024.6-2026.5。

主要获奖和荣誉

2024年起担任 Life Sciences 期刊的Editorial Board member；

2023年美高梅赌场 院级先进工作者；

2022-2023年度河北师范大学本科教学质量优秀教师奖；

2020-2021学年河北师范大学汇华美高梅赌场 教学优秀奖；  

2019年河北省高等教育教学成果二等奖（第2完成人）；

2019年河北省普通本科院校优秀教学团队成员；

2018-2019年度河北师范大学本科毕业论文优秀指导教师；

2018年第三批河北省“巨人计划”创新创业团队成员；

代表性科研论文

1.              Cao P^#, Aoki Y#, Badri L, Walker N, Lagstein A, Fearon ER,Lama VN. Autocrine lysophosphatidic acid signaling activates β-catenin andpromotes lung allograft fibrosis. J Clin Invest. 2017,127(4):1517-1530. (^#Contributedequally)

2.              Zhu Y^#, Chang J^#, Tan K^#, Steven KH, Liu X, Wang X,Cao M, Zhang H, Li S, Duan X, Chang Y, Fan Y^#, Cao P^#*. Clioquinol attenuates pulmonary fibrosis throughinactivation of fibroblasts via iron chelation. American Journal ofRespiratory Cell and Molecular Biology. 2021, 65(2):189-200. (^#Contributedequally. *Corresponding author.)

3.              Wang Y, Wang X, Du C, Wang Z, Wang J, Zhou N, WangB, Tan K*, Fan Y*, Cao P*. Glycolysis and beyond in glucose metabolism: exploring pulmonary fibrosisat the metabolic crossroads. Frontiers in Endocrinology. 2024,15:1379521. (*Corresponding author.)

4.              Cao P*, Ji H*, Sun J*. Editorial:Pulmonary fibrosis and endocrine factors. Frontiersin Endocrinology. 2024, 15:1519318. (*Corresponding author.)

5.              Chang J^#, Wang J^#, Luo B^#,Li W, Xiong Z, Du C, Wang X, Wang Y, Tian J, Li S, Fang Y, Li L, Dong J, Tan K*, Fan Y*, Cao P*. Vitamin E stabilizes iron and mitochondrial metabolism in pulmonaryfibrosis, Frontiers in Pharmacology, 2023, 14: 1240829. (^#Contributed equally. *Corresponding author.)

6.              Liu X^#, Wang X^#,Chang J, Zhang H, Cao P*.Landscape analysis and overview of the literature on oxidative stress andpulmonary diseases. Frontiers in Pharmacology. 2023,14:1190817. (^#Contributedequally. *Corresponding author.)

7.              Wang G^#, Fan Y^#,Cao P^#, Tan K*. Insight into the mitochondrialunfolded protein response and cancer: opportunities and challenges. CellBiosci. 2022,18;12(1):18. (^#Contributedequally. *Corresponding author.)

8.              He S^#, Xue  J^#, Cao P^#, Hou J, Chang J, Huang L, Han Y, Duan X, TanK*, Fan Y*. JNK/Itch Axis Mediates the Lipopolysaccharide‑InducedUbiquitin–Proteasome–Dependent Degradation of Ferritin Light Chain in MurineMacrophage Cells. Inflammation. 2022,45(3):1089-1100. (^#Contributed equally.*Corresponding author.)

9.              Liu X^#, Liu B^#, Shang Y^#,Cao P^#, Hou J,Chen F, Zhang B, Fan Y*, Tan K*. Decreased TMPRSS2 expression by SARS-CoV-2predicts the poor prognosis of lung cancer patients through metabolic pathwaysand immune infiltration. Aging (Albany NY). 2022,14(1):73-108. (^#Contributed equally.*Corresponding author.)

10.           Li S^#,Zhang H^#, Chang J, Li D*, Cao P*. Iron overloadand mitochondrial dysfunction: orchestrating the progression of pulmonaryfibrosis. European Journal of Pharmacology. 2021,912:174613. (^#Contributedequally. *Corresponding author.)

11.           Chen F^#, Fan Y^#,Cao P^#, Liu B, Hou J, Zhang B, Tan K*. Pan-CancerAnalysis of the Prognostic and  Immunological Role of HSF1: A Potential Targetfor Survival and Immunotherapy. Oxid Med CellLongev. 2021,18:2021:5551036. (^#Contributed equally. *Corresponding author.)

12.           Fang Y, TianJ, Fan Y, Cao P. Latest progress on the molecular mechanisms ofidiopathic pulmonary fibrosis. MolBiol Rep. 2020;47(12):9811-9820.

13.           Cao P, WalkerNM, Braeuer RR, Mazzoni-Putman S, Aoki Y,  Misumi K, David S Wheeler DS, Vittal R, Lama V N*. Loss of FOXF1 expression promotes humanlung-resident mesenchymal stromal cell migration via ATX/LPA/LPA1  signalingaxis. Scientific Reports. 2020,10(1):21231.

14.           Shao J^#, Han B^#, Cao P^#, Zhang B, Liu M, Li D,Zhou N, Hao Q, Duan X, Chang Y, Nakai A, Fan Y, Tan K. HSF1 phosphorylationby cyclosporin A confers hyperthermia sensitivity through suppression of HSPexpression. BiochimBiophys Acta Gene Regul Mech. 2019,1862(8):846-857. (^#Contributed equally.)

15.           Cao P^#, Sun W^#, Kramp K, Zheng M, Salom D, Jastrzebska B, Jin H,Palczewski K*, Feng Z*.Light-sensitive coupling of rhodopsin and melanopsin to Gi/o and Gq signaltransduction in Caenorhabditis elegans. FASEBJ. 2012,26(2):480-491. (^#Contributed equally. *Corresponding author.)

16.           David S^#, Cao P^#,Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z*, Palczewski K*. Heterologous expression of functionalG-protein-coupled receptors in Caenorhabditis. FASEB J. 2012,26(2):492- 502. (^#Contributed equally. *Corresponding author.)

17.           Cao P^#, Yuan Y^#, Pehek E, Moise A, Huang Y, Palczewski K., Feng Z*. Alpha-synuclein disrupted dopamine homeostasisleads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS ONE. 2010,5(2), e9312. (^#Contributedequally. *Corresponding author.)

18.           Cao P^#, Song J,Zhou C, Weng M, Liu J, Wang F, Zhao F, Feng D*, Wang B*. Characterization of multiple cold induced genesfrom Ammopiptanthus mongolicus and functional analyses of gene AmEBP1. Plant Molecular Biology. 2009,69(5), 529-539. (^#Contributed equally. *Corresponding author.)

19.           FeiY^#, Cao P^#, Gao S, Wang B, Wei L, Zhao J, ChenG, Wang B. (2008) Purification and analysis of antifreeze proteins from aligneous plant. Preparative Biochemistryand Biotechnology. 2008,38(2),172-183.(^#Contribute equally.)

20.           FeiY^#, Cao P^#, Gao S, Wei L. & Wang B.Discovery of a homolog of siderophilin in a plant. Journal of Integrative Plant Biology. 2005,47(12),1409-1411. (^#Contributeequally.)

21.           Chen S, CaoP, Zhang C, Peng J, WangH, Miller RE, Malfait AM, Zhou Y, Zhou T, Dong N, Wu Q. (2015) PCSK6-mediatedcorin activation is essential for normal blood pressure. Nature Medicine. 2015,21(9):1048-1053.

22.           Li D, LiuB, Fan Y , LiuM, Han, ,Meng Y , Xu X , Song Z, Liu X, Hao Q, Duan X , Nakai A, Chang Y , Cao P, Tan K. Nuciferine protects against folicacid-induced acute kidney injury by inhibiting ferroptosis. Br J Pharmacol. 2021;178(5):1182-1199.

23.           Zhou N,Cui Y, Zhu R, Kuang Y, Ma W, Hou J, Zhu Y, Chen S, Xu X, Tan K, CaoP, Duan X, Fan Y. Deferasirox showsinhibition activity against cervical cancer in vitro and in vivo. Gynecol Oncol. 2022,166(1):126-137.

24.           Chen F,Fan Y, Liu X, Zhang J, Shang Y, Zhang B, Liu B, Hou J, Cao P, TanK. Pan-Cancer Integrated  Analysis  of HSF2 Expression,Prognostic Value and Potential Implications for Cancer Immunity. Front Mol Biosci. 2022,11;8:789703.

25.           Chen F,Han B, Meng Y, Han Y, Liu B, Zhang B, Chang Y, Cao P, FanY, Tan K. Ceruloplasmin correlates with immune infiltration andserves as a prognostic biomarker in breast cancer. Aging (Albany NY). 2021,13(16):20438-20467.

26.           Li M, Nabi G, Sun Y, Wang Y, Wang L, Jiang C, Cao P, Wu Y, Li D. The effect ofair pollution on immunological, antioxidative and hematological parameters, andbody condition of Eurasian tree sparrows. Ecotoxicol Environ Saf.2021;208:111755.

27.           Liu M,Fan Y, Li D, Han B, Meng Y, Chen F, Liu T, Song Z, Han Y, Huang L, Chang Y, CaoP, Nakai A, Tan K. Ferroptosis inducererastin sensitizes NSCLC cells to celastrol through activation of theROS-mitochondrial fission-mitophagy axis. Mol Oncol. 2021,15(8):2084-2105.

28.           Liu B,Song Z, Fan Y, Zhang G, Cao P, Li D, Liu X, ChangY, Tan K.Downregulation ofFPN1 acts as a prognostic biomarker associated with immune infiltration in lungcancer.Aging (Albany NY).2021,13(6):8737-8761.

29.           Fan Y,Liu B, Chen F, Song Z, Han B, Meng Y, Hou J, Cao P, ChangY, Tan K.Hepcidin Upregulation in Lung Cancer: A PotentialTherapeutic Target Associated With Immune Infiltration. Front Immunol. 2021,12:612144.

30.           Liu B,Fan Y, Song Z, Han B, Meng Y, Cao P, Tan K. Identification ofDRP1 as a prognostic factor correlated with immune infiltration in breastcancer.IntImmunopharmacol.2020,89(Pt B):107078.

31.           Chen F,Fan Y, Hou J, Liu B, Zhang B, Shang Y, Chang Y, Cao P, TanK. Integrated analysisidentifies TfR1 as a prognostic biomarker which correlates with immuneinfiltration in breast cancer. Aging (Albany NY). 2021,13(17):21671-21699.

32.           Fan Y, Hou J, LiuX, Han B, Meng Y, Liu B, Chen F, Shang Y, Cao P, Tan K. IntegratedBioinformatics Analysis Identifies Heat Shock Factor 2 as a PrognosticBiomarker Associated With Immune Cell Infiltration in Hepatocellular Carcinoma. Front Genet. 2021,12:668516.

33.           ChenY, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, FengZ, Palczewski K. Inherent instability of the retinitis pigmentosa P23H mutantopsin. The Journal of BiologicalChemistry. 2013,289(13):9288-9303.

34.           YuanY, Hakimi P, Kao C, Kao A, Liu R, Janocha A, Boyd-Tressler A, Hang X, AlhoraibiH, Slater E, Xia  K, Cao P, Shue Q, Ching TT, Hsu AL, ErzurumSC, Dubyak G.R, Berger N.A, Hanson R.W, Feng Z. Reciprocal Changes inPhosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are aDeterminant of Aging in Caenorhabditis elegans. The Journal of Biological Chemistry. 2016,291(3):1307-1319.

35.           YuanY, Cao P, Smith M, Kramp K, Huang Y, HisamotoN, Matsumoto K, Hatzoglou M, Jin H, Feng Z. Dysregulated LRRK2/p38 signaling inresponse to endoplasmic reticulum stress leads to dopaminergic neurondegeneration. PLoS ONE. 2011,6 (8):e22354.

36.           ZhengM, Cao P, Yang J, Xu, X.Z, Feng Z. Calciumimaging of multiple neurons in freely behaving C. elegans. Journal of Neuroscience Methods. 2012,206 (1),78–82.

37.           SalomD, Cao P, Yuan Y, Miyagi M, Feng Z, PalczewskiK. Isotopic labeling of mammalian G protein-coupled receptors heterologouslyexpressed in Caenorhabditis elegans. AnalBiochem. 2015,472:30-36.

38.           ZhouC, Chen C, Cao P, Kong F, Sun J. & Wang B.Characterization and fine mapping of RppQ, a resistance gene to southern cornrust in maize. Molecular Genetics andGenomics. 2007,78 (6),723-728.

39.           JastrzebskaB, Salom D, Jin H, Cao P, Sun W, Palczewski K, Feng Z.Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods in Enzymology.2013,520:239-256.

40.           LiangF, Kong F, Zhou C, Cao P, Ye C. & Wang B. Cloning andcharacterization of a non-TIRNBS-LRR type disease resistance gene analogue frompeach. DNA Sequence. 2005,16 (2),103-110.

41.           SongJ, Liu J, Weng M, Huang Y, Luo L, CaoP, Sun H, Liu J, Zhao J,Feng D, Wang B. Cloning of Galactinol Synthase Gene from AmmopiptanthusMongolicus and its expression in transgenic Photinia serrulata plants. Gene. 2013,513(1):118-127.

42.           BaiL, Ye C, Lu J, Yang D, Xue H, Pan Y, CaoP, Wang B, & Liu M.Ipt gene transformation in petunia by an Agrobacterium mediated method. Journalof Immunoassay and Immunochemistry. 2009,30 (2):224-231.

43.           WangJ, Qi Z, Niu L, Cao P, Cao X. DNA Extraction and RAPDAnalysis of Different Ostreatus Strains. EdibleFungi. 2007,29 (1),13-14.