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汤文强
发布时间：2017-04-18
一、工作和学习经历
1990.9-1994.6 兰州大学生物系细胞生物学专业 学士
1994.7-1998.1 河北师范大学生物系 实习研究员
1999.1-2004.5 美国德克萨斯大学奥斯汀分校植物系 博士
2004.8-2009.9 美国斯坦福大学卡耐基研究院植物系 博士后
2014.8-2015.8 美国加州大学旧金山分校药学系质谱中心 访问学者
2010.1至今 美高梅赌场-线上赌场网站
教授
二、研究方向:
目前实验室的研究兴趣主要集中在以下两个方面：
(1) 油菜素内酯对植物生长发育调控的作用机理。
作为植物的主要生长调节激素之一，BR 在植物生长发育的各个时期都发挥着重要作用。生理学实验表明，外加BR 能诱导广普的植物生理反应，包括种子萌发，胚轴和茎的生长，木质部的分化，叶片卷曲和偏上生长(epinasty)，根的生长和向重力反应，植物抗病和逆境胁迫反应等等。近年来的研究也发现通过分子生物学手段在水稻等作物不同的组织中有选择地增强或减弱内源BR的信号可以成为作物品种改良的一种新的手段和方向。
利用双子叶模式植物拟南芥为材料，对于 BR 信号转导途径的研究取得了许多突破性的进展，并得出一个基本清晰的路径图。在该路径中，BR和质膜受体BRI1结合后促进BRI1和共受体BAK1相互磷酸化，并通过质膜上蛋白激酶BSK或CDG1调节下游蛋白磷酸酶BSU1的活性。BSU1将蛋白激酶BIN2去磷酸化从而抑制BIN2对转录因子BZR1/BES1的磷酸化作用。磷酸化的BZR1/BES1被蛋白磷酸酶PP2A去磷酸化，结合在DNA上，调节BR相关的基因表达。虽然目前关于BR信号传递途径的研究取得了巨大的进展，对于其中的一些关键步骤的调节机制我们了解得还是不太清楚。因此我们拟通过对这些BR上游信号传递蛋白的相互作用组（interactome）的研究来寻找它们的相互作用蛋白，同时筛选这些组分家族的T-DNA插入突变体来进一步揭示BR信号传递途径的调节机制，为BR信号调节植物生长发育的分子机理打下基础。
（2）植物热激信号传导机理。
随着人类工业化进程的加剧，温室效应导致的全球温度升高是一个不争的事实。最近30多年来，全球平均温度已经升高了近1度。统计学研究发现全球平均温度每升高1度，将导致水稻减产3.2%，玉米减产7.4%，大豆减产3.1%，小麦减产6%。因此研究植物抵抗高温的分子机制将有利于开发重要植物耐热标记基因，帮助培育高产耐热作物新品种，具有重要的理论和生产应用价值。我实验室主要关注植物如何感受环境高温的变化，并调节基因表达来提高植物耐热性的早期热激信号传导机制。实验室前期工作已建立早期热激信号被激活的分子评估体系，目前正在寻找热激信号传导新组分，尤其是能调节HSFA1s蛋白活性和蛋白稳定性的新组分，并解析植物早期热激记忆形成的分子机制。
三、承担科研项目：
1. 国家级项目
1) 国家自然科学基金面上项目（2011-2013, 2017-2020, 2019-2022, 2021-2024,2023-2026, 2025-2028，主持）
2) “植物激素作用的分子机理”重大研究计划集成项目（2015，主持）
3) “植物激素作用的分子机理”重大研究计划培育项目（2010-2012，主持）
4) “植物胚胎和种子发育的机理研究”973子课题（2014-2018，参加）
5) 农业部转基因重大专项子课题（2010, 2013-2015，参加）
2. 省级项目
1) 河北省自然科学基金重点项目（2020-2022，主持）
2) 河北省应用基础研究计划重点基础研究项目（2015-2017，主持）
3) 河北省高等学校创新团队领军人才培育计划（2014-2016，主持）
4) 河北省百人计划（2012-2016，主持）
5) 河北省杰出青年项目（2011-2013，主持）
6) 河北省百名优秀创新人才支持计划（2010-2012，主持）
7) 河北省留学回国基金（2010-2012，主持）
四、承担教学任务：
1. 本科生《细胞生物学》双语课
2. 研究生《细胞信号传导》
五、所获专利:
1. “拟南芥HIRK1基因及其同源基因在提高植物耐热能力方面的应用”，专利号(ZL202210486577.2), 申请日：2022/05/06；授权公告日：2024/6/7；发明人：任卉敏、汤文强
2. “调节谷子种子大小的基因及其编码的蛋白质和应用”，专利号(ZL202011101245.5), 申请日：2020/10/15；授权公告日：2022/7/19；发明人：汤文强、赵志英
3. “GBP蛋白及其编码基因在调控植物产量中的应用”, 专利号(ZL201710532910.8)，申请日：2017/7/3；授权日：2020/12/29；发明人：汤文强、安志超、张宝文
4. “水稻敏热基因UBP21的应用”，专利号(ZL201410745025.4), 申请日：2014/12/09； 授权日：2018/9/18；发明人：汤文强、张宝文、安志超
5. "水稻基因BSK3的应用”，专利号(ZL201410832924.8), 申请日：2014/12/29；授权日：2017/11/14；发明人：汤文强、张宝文
6. “Newisolated nucleic acid molecule comprising a sequence of nucleotides thatencodes a brassinosteroid receptor regulated kinase useful for producingtransgenic plants and modulating cellular process of a plant cell”. 专利号：WO2010011285-A2;US2010043097-A1. 发明人：Wenqiang Tang and Zhiyong Wang
六、所获奖励：
1. “油菜素内酯信号传导及其调控植物生长发育的分子机制”项目获2020年度河北省科学技术奖(自然科学奖)一等奖
七、代表性论文
1. ZhangY, Han L, Liu J, Chang M, Li C, Shang J, Deng Z*, Tang W*,Sun Y* (2025) Two E-clade Protein Phosphatase 2Cs enhance ABAsignaling by dephosphorylating ABI1 in Arabidopsis. Molecular Plant(accepted)
该论文发现了两个能将ABI1第117位丝氨酸去磷酸化来调节ABI1蛋白稳定性和活性的E家族PP2C蛋白磷酸酶，研究结果为解析ABA信号传导的调控机制提供了新的调控组分。
2. Li B,Jiang S, Gao L, Wang W, Luo H, Dong Y, Gao Z, Zheng S, Liu X*, Tang W*(2024) Heat Shock Factor A1s are required for phytochrome-interaciing factor4-mediated thermomorphogenesis in Arabidopsis. J Integr Plant Biol.66(1):20-35 (Cover story)
该论文发现HSFA1能通过调节PIF4的转录和蛋白稳定性调节植物的高温形态建成过程，证明了植物温和高温和热激高温响应不是两个独立的生物学过程。
3. Wu X,Cai X, Zhang B, Wu S, Wang R, Li N, Li Y, Sun Y*, Tang W* (2022) ERECTAregulates seed size independently of its intracellular domain viaMAPK-DA1-UBP15 signaling. Plant Cell 34(10): 3773-3789
该论文发现了种子发育过程中母体遗传调控珠被细胞分裂的近完整的信号通路：ER-MAPK-DA1-UBP15。
4. Wang R, Wang R, Liu M, Yuan W, Zhao Z, Liu X,Peng Y, Yang X, Sun Y, Tang W*(2021) Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT 1 in Arabidopsis thaliana. Proc. Natl. Acad.Sci. U.S.A. 118(33):e2101838118
该论文证明了BR能迅速将胞质中磷酸化的BZR1招募到细胞核中，并在细胞核中去磷酸化，同时还提出了去磷酸化的BZR1也能被26S蛋白酶体途径降解。
5. Li B,Gao Z, Liu X, Sun D, Tang W* (2019)Transcriptional Profiling Reveals a Time-of-Day-Specific Role of REVEILLE 4/8in Regulating the First Wave of Heat Shock–Induced Gene Expression inArabidopsis. Plant Cell 31: 2353-2369
该论文发现生物钟核心调控元件RVE4/8能独立于HSFA1s途径快速调节热激高温响应基因的表达，调节植物在中午时对环境高温的耐受能力。
6. Chen L,Gao Z, Zhao Z, Liu X, Li Y, Zhang Y, Liu X, Sun Y and Tang W* (2019) BZR1 Family Transcription Factors FunctionRedundantly and Indispensably in BR Signaling but Exhibit BRI1-IndependentFunction in Regulating Anther Development in Arabidopsis. Molecular Plant 12:1408-1415
该论文证明了BZR1家族转录因子是BR信号途径不可缺失的组分
7. Li B,Gao K, Ren H and Tang W*. (2018)Molecular mechanisms governing plant responses to high temperatures. JIntegr Plant Biol. 60(9):757-779 (Invited Expert Review)
该论文系统论述了植物响应高温的信号途径，多次入选ESI高被引论文。
8. An Z, Liu Y, Ou Y, Li J, Zhang B, Sun D,Sun Y*, Tang W*. (2018) Regulation of the stability of RGF1 receptor bythe ubiquitin-specific proteases UBP12/UBP13 is critical for root meristemmaintenance. Proc. Natl. Acad. Sci. U.S.A. 115(5):1123-1128
该论文发现了一个RGF1-RGIs信号途径新成员UBP12/13，证明UBP12/13能通过将RGI1去泛素化，调节植物根对RGF1的响应。
9. Wang R,Liu M, Yuan M, Oses-Prieto JA, Cai X, Sun Y, Burlingame A, Wang Z, Tang W*.(2016) The brassinosteroid activated BRI1 receptor kinase is switched off bydephosphorylation mediated by cytoplasm-localized PP2A B’ subunits. MolecularPlant 9(1):148-157.
该论文发现PP2A能将BRI1去磷酸化关闭BR信号，并提出了BZR1可能在细胞核中被去磷酸化的观点。
10. Tang W*, YuanM*, Wang R*, Yang Y*, Wang C, Oses-Prieto JA, Kim TW, Zhou H, Deng Z, GampalaSS, Gendron JM, Jonassen EM, Lillo C, DeLong A, Burlingame AL, Sun Y &Wang ZY. (2011) PP2A activates brassinosteroid responsivegene expression and plant growth by dephosphorylating BZR1. NatureCell Biology 13(2):124-131. (*equal contribution)
该论文发现了一个BR信号传导途径的新成员PP2A，证明PP2A能将BZR1去磷酸化激活BR信号途径。
11. Tang W, KimTW, Oses-Prieto JA, Sun Y, Deng Z, Zhu S,Wang R, Burlingame AL, and Wang ZY (2008) BSKs mediate signaltransduction from the receptor kinase BRI1 in Arabidopsis. Science 321(5888):557-560.
该论文发现了一个BR信号传导途径的新成员BSK1/2, 证明BSK1/2作用在受体BRI1的下游将BR信号从细胞膜上传递到细胞质中。
八、其他发表论文
12. Ning K,Li X, Yan J, Liu J, Gao Z, Tang W*, Sun Y* (2025) Heat stress inhibitspollen development by degrading mRNA capping enzyme ARCP1 and ARCP2. PlantCell Environ. 48(2):978-991
13. Cai X,Lee S, Jaime APG, Tang W, Sun Y, Huq E* (2024) Phosphatase 2Adephosphorylates PHYTOCHROME-INTERACTING FACTOR3 to modulate photomorphogenesisin Arabidopsis. Plant Cell. 36(10)4457-4471.
14. Shi L,Li C, Lv G, Li X, Feng W, Bi Y, Wang W, Wang Y, Zhu L, Tang W, Fu Y*(2024) The adaptor protein ECAP, the corepressor LEUNIG, and the transcriptionfactor BEH3 interact and regulate microsporocyte generation in Arabidopsis. PlantCell. 36(7) 2531-2549
15. Li S,Yan J, Chen LG, Meng G, Zhou Y, Wang CM, Jiang L, Luo J, Jiang Y, Li QF, TangW*, He JX* (2024) Brassinosteroid regulates stomatal development inetiolated cotyledons via transcription factors BZR1 and BES1. PlantPhysiol. 195(2):1382-1400
16. Li C,Li X, Deng Z, Song Y, Liu X, Tang X, Li Z, Zhang Y, Zhang B, Tang W,Shang J* and Sun Y* (2024) EGR1 and EGR2 positively regulate plant ABAsignaling by modulating the phosphorylation of SnRK2.2. New Phytol.241(4): 1492-1509
17. Tang S,Zhao Z, Liu X, Sui Y, Zhang D, Zhi H, Gao Y, Zhang H, Zhang L, Wang Y, Zhao M,Li D, Wang K, He Q, Zhang R, Zhang W, Jia G, Tang W, Ye X, Wu C*, Diao X*(2023) An E2-E3 pair contributes to seed size control in grain crops. NatCommun. 14(1):3091
18. Wang D,Li Y, Wang H, Xu Y, Yang Y, Zhou Y, Chen Z, Zhou Y, Gui L, Guo Y, Zhou C, TangW, Zheng S, Wang L, Guo X, Zhang Y, Cui F, Lin X, Jiao Y, He Y, Li J, He F,Liu X*, Xiao J* (2023) Boosting wheat functional genomics via an indexed EMSmutant libraray of KN9204. Plant Commun. 4(4)100593
19. Ren H,Wu X, Zhao W, Wang Y, Sun D, Gao K*,Tang W* (2022) Heat Shock-InducedAccumulation of the Glycogen Synthase Kinase 3-Like Kinase BRASSINOSTEROIDINSENSITIVE 2 Promotes Early Flowering but Reduces Thermotolerance inArabidopsis. Front Plant Sci. 13:838062
20. Zhang H,Guo L, Li Y, Zhao D, Liu L, Chang W, Zhang K, Zheng Y, Hou J, Fu C, Zhang Y,Zhang B, Ma Y, Niu Y, Zhang K, Sing J, Cui S, Wang F, Tan K, Zheng S, Tang W, Dong J*, Liu X* (2022)TOP1a fine-tunes TOR-PLT2 to maintain root tip homeostasis in response tosugars. Nature Plant 8(7):792-801
21. Li M,Li P, Wang C, Xu H, Wang M, Wang Y, Niu X, Xu M, Wang H, Qin Y, Tang W, Bai M, Wang W, Wu S (2022)Brassinosteroid signaling restricts root lignification by antagonizingSHORT-ROOT function in Arabidopsis. Plant Physiology 190(2):1182-1198
22. Zhao Z, Tang S, Li W, Yang X, Wang R, Diao X*, Tang W* (2021) Overexpressionof a BRASSINAZOLE RESISTANT 1 homolog attenuates drought tolerance bysuppressing the expression of PLETHORA-LIKE 1 in Setaria italica.Crop J. 9(5):1208-1213
23. Tian Y,Zhao N, Wang M, Zhou W, Guo J, Han C, Zhou C, Wang W, Wu S, Tang W, FanM, Bai M (2021) Integrated regulation of periclinal cell division bytranscriptional module of BZR1-SHR in Arabidopsis roots. New Phytologist 233(2):795-808
24. Zho Z, Tang S, Zhang Y, Yue J, Xu J, Tang W, Sun Y,Wang R, Diao X*, Zhang B* (2021) Evolutionary analysis and functionalcharacterization of SiBRI1 as a brassinosteroid receptor gene in foxtailmillet. BMC Plant Biology 21:291
25. Tian X,He M, Mei E, Zhang B, Tang J, Xu M, Liu J, Li X, Wang Z, Tang W, Bu Q* (2021) WRKY53Integrates Classic Brassinosteroid Signaling and the Mitogen-Activated ProteinKinase Pathway to Regulate Rice Architecture and Seed Size. PlantCell 33(8): 2753-2775
26. Zhao M,Tang S, Zhang H, He M, Liu J, Zhi H, Sui Y, Liu X, Jia G, Zhao Z, Yan J, ZhangB, Zhou Y, Chu J, Wang X, Zhao B, Tang W, Li J, Wu C*, Liu X* andDiao X* (2020)DROOPY LEAF1 controls leaf architecture by orchestrating early brassinosteroidsignaling. Proc. Natl. Acad. Sci. U.S.A. 117(35):21766-21774
27. Jia D,Chen LG, Yin G, Yang X, Gao Z, Guo Y, Sun Y and Tang W* (2020)Brassinosteroids regulate outer ovule integument growth in part via the controlof INNER NO OUTER by BRASSINOZOLE-RESISTANT family transcription factors. JIntegr Plant Biol. 62(8):1093-1111 (Cover story)
28. Zhou H,Wang X, Huo C, Wang H, An Z, Sun D, Liu J, TangW* and Zhang B* (2019) AQuantitative Proteomics Study of Early Heat-Regulated Proteins byTwo-Dimensional Difference Gel Electrophoresis Identified OsUBP21 as a NegativeRegulator of Heat Stress Responses in Rice. Proteomics 19:e1900153 (*co-corresponding authors, Cover story)
29. Gao Z,Zhao Z, Tang W* (2018) DREAMSeq: animproved method for analyzing differentially expressed genes in RNA-seq data. Frontiers in Genetics 9:588
30. 霍晨敏、汤文强 (2016) 植物冷信号传导机制研究进展 生物技术通报 10:27-33 (特约综述)
31. Yang X,Bai Y, Shang J, Xin R, Tang W*.(2016) The Antagonistic Regulation of Abscisic Acid-Inhibited Root Growth byBrassinosteroids is Partially Mediated via Direct Suppression of ABSCISIC ACIDINSENSITIVE 5 Expression by BRASSINAZOLE RESISTANT 1. Plant, Cell & Environment39(9):1994-2003
32. Zhang B,Wang X, Zhao Z, Wang R, Huang X, Zhu Y, Yuan L, Wang Y, Xu X, Burlingame AL, GuoY, Sun Y, Tang W*. (2016) OsBRI1 activates BR signaling by preventingbinding between the TPR and kinase domains of OsBSK3 via phosphorylation. PlantPhysiology 170(2):1149-1161.
33. Huo C, ZhangB, Wang H, Wang F, Liu M, Gao Y, Zhang W, Deng Z, Sun D, Tang W*. (2016)Comparative study of early cold-regulated proteins by two dimentionaldifference gel electrophoresis reveals a key role for phospholipase Da1 inmediating cold acclimation signaling pathway in rice. Molecular &Cellular Proteomics 15(4):1397-1411.
34. Wang X， Ma X, Wang H, LiB, Clark G, Guo Y, Roux S, Sun D and Tang W*, (2015) Proteomic study ofmicrosomal proteins reveals a key role for Arabidopsis Annexin 1 in mediatingheat stress-induced increase in intracellular calcium levels. Molecular& Cellular Proteomics 14(3):686-694.
35. Xu P,Xu S, Li Z, Tang W, BurlingameAL and Wang ZY (2014) A brassinosteroid signaling kinase interacts withmultiple receptor-like kinases in Arabidopsis. Molecular Plant 7(2):441-444.
36. Tang W* (2012) Quantitative proteomic analysis ofplasma membrane using two-dimensional difference gel electrophoresis (2-DDIGE). Methods in Molecular Biology 876:67-82.
37. Liu X,Wu J, Clark G, Lundy S, Lim M, Arnold D, Chan J, Tang W, Muday GK,Gardner G, Roux SJ (2012). Role for apyrases in polar auxin transport inArabidopsis. Plant Physiology 160(4):1985-1995
38. SamuelMA, Tang W, Jamshed M, Northey J, Patel D, Smith D, Siu M, MuenchDG, Wang ZY, and Goring DR (2011) Proteomic analysis of Brassica stigmaticproteins following the self-incompatibility reaction reveals a role formicrotubule dynamics during pollen responses. Molecular & CellularProteomics 10(12):M111.011338.
39. Tang W, Deng Z and Wang ZY (2010)Proteomics shed light on the brassinosteroid signaling mechanism. CurrentOpinion in Plant Biology 13(1):27-33.
40. Sun Y,Fan X, Cao D, Tang W, He K, Zhu J, He JX, Bai MY, Zhu S, Oh E, Patil S,Kim TW, Ji H, Wong W, Rhee S, Wang ZY (2010) Integration of BrassinosteroidSignal Transduction with the Transcription Network for Plant Growth Regulationin Arabidopsis. Development Cell 19(5):765-777.
41. Kim TW,Guan S, Sun Y, Deng Z, Tang W,Shang J, Sun Y, Burlingame AL and Wang ZY (2009) Brassinosteroid signaltransduction from cell-surface receptor kinases to nuclear transcriptionfactors. Nature Cell Biology 11(10):1254-1262.
42. Tang W, Deng Z,Oses-Prieto JA, Suzuki N, Zhu S, Zhang X, Burlingame AL, and Wang ZY (2008) Proteomic studies of brassinosteroid signaltransduction using prefractionation and 2-D DIGE. Molecular &Cellular Proteomics 7(4):728- 738.
43. Deng Z,Zhang X, Tang W, Oses-Prieto JA, Suzuki N, Gendron JM, Chen H, Guan S, ChalkleyRJ, Peterman TK, Burlingame AL and Wang ZY (2007) A proteomic study ofbrassinosteroid response in Arabidopsis. Molecular & CellularProteomics 6(12):2058-2071
44. GampalaSS, Kim TW, He J, Tang W,Deng Z, Bai M, Guan S, Lalonde S, Sun Y, Gendron JM, Chen H, Shibagaki N, FerlRJ, Ehrhardt D, Chong K, Burlingame AL and Wang ZY (2007) An Essential Role for14-3-3 Proteins in Brassinosteroid Signal Transduction in Arabidopsis. DevelopmentalCell 13(2):177-189
45. Tang W, Brady SR, Sun Y,Muday GK, and Roux SJ (2003) ExtracellularATP Inhibits Root Gravitropism at Concentrations That Inhibit Polar AuxinTransport. PlantPhysiology 131, 147-154
46. Jeter C*,Tang W*, Henaff E, Butterfield T, and Roux SJ (2004) Evidence of a NovelCell Signaling Pathway in Arabidopsis Induced by Extracellular Nucleoside Tri-and Diphosphates. Plant Cell 16, 2652- 2664 (*equal contribution)
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